Objective To systematically evaluate the effect of symptom cluster management on symptom cluster severity and interfe-rence in daily life in cancer survivors. Methods Randomized controlled trials （RCTs） reporting the effect of management interventions on symptom clusters in cancer survivors were retrieved in electronic databases from inception to May, 2019. RevMan5.3 was used for statistical analysis. Results Eight RCTs were included for analysis. The improvements in symptom cluster severity ［SMD=-0.42,95%CI（-0.54, -0.30）］ and interference in daily life ［SMD=-0.62,95%CI（-1.15,-0.09）］ in the intervention group were significantly better compared with the control group. Conclusion Symptom cluster management could effectively alleviate symptom cluster severity and interference in daily life in cancer patients.