Objective To create a hierarchical-round, three-step, closed-loop management system based on information analysis technology and to evaluate its application effect. Methods Based on the hospital information system, a hierarchical-round, three-step of execution-feedback-analysis, closed-loop management system was developed for medical-nursing mobile terminal, and the effects were evaluated before and after the application. Results Nursing quality was improved, the incidence of adverse nursing events was reduced, the detection rate of potential nursing safety hazards was increased, patient′s experience of hospitalization and nurses′ sa-tisfaction with their own nursing quality and safety work execution were enhanced, as well as nursing practice environment was improved after application of the system (P＜0.05,P＜0.01). Conclusion The application of hierarchical-round, three-step, closed-loop management system based on information analysis technology can improve nursing quality.