Objective To compare complications and health-promoting behaviors between venous access port （VAP） and peripherally inserted central venous catheter （PICC） in breast cancer patients, thus to provide reference for taking measures to promote health of patients. Methods A total of 135 breast cancer patients who received VAP and 278 patients who placed with PICC were studied. Complications were recorded within 6 months of catheterization, and the Health Promotion Lifestyle Scale（HPLP） was used for questionnaire survey. Results Patients with VAP had lower incidence rate of complications and higher score of health-promoting behaviors compared with their counterparts with PICC (P＜0.05,P＜0.01). Conclusion Compared with PICC, VAP leads to fewer complications and better health-promoting behaviors in breast cancer patients. Breast cancer patients with PICC should be paid more attention to, thus to help them adopt healthy behaviors.