Objective To investigate the status and determinants of sarcopenia in patients with Crohn′s disease, and to provide refe-rence for targeted intervention. Methods A total of 188 patients with Crohn′s disease completed a battery of questionnaires including the Multidimensional Fatigue Inventory, Nutrition Risk Screening 2002 and International Physical Activity Questionnaire Short Form.Body composition analyzer was employed to assess sarcopenia. Results The proportion of normal participants and those with presarcopenia, sarcopenia and severe sarcopenia was 29.8%, 31.9%, 16.5%, and 21.8%, respectively. Regression analysis showed that gender, body mass index, fatigue, disease activity and complication were risk factors of sarcopenia in patients with Crohn′s disease （P＜0.05,P＜0.01）. Conclusion The prevalence of sarcopenia was high in patient with Crohn′s disease and affec-ted by several factors. Attention should be paid to those who are male, who have low body mass index, who have severe fatigue, who are at active stage of disease and who have more complications.