Objective To analyze the relationship among stigma, depression and glucose control among patients with type 2 diabetes mellitus(T2DM). Methods A total of 209 hospitalized patients with T2DM were recruited and fill out the Type 2 Diabetes Stigma Assessment Scale (DSAS-2) and Self-Rating Depression Scale （SDS）. Patients′general information and glycemic control indicators were collected. Results The total score of DSAS-2 was (52.52±10.75) points, the score of being treated differently, blame and judgment, and self-stigma averaged (16.29±3.99) points, (18.70±3.69) points, (17.54±5.12) points respectively. The patients scored （44.06±9.69）points in SDS, with 66 patients (31.58%) in presenting depressive symptoms. DSAS-2 scores varied significantly by whether presenting depressive symptoms or not, and normal vs. abnormal glucose levels(P<0.01 for both). Patients′ fasting plasma glucose and HbA1c levels were positively correlated with SDS scores(P<0.01 for both).SDS scores were positively correlated with DSAS-2 total and dimension scores, likewise glucose levels with DSAS-2 total and dimension scores(P<0.01 for all). Conclusion The stigma of T2DM patients was at a low to medium level. There was a positive correlation between stigma or depression alone, and glucose levels in patients with T2DM. Medical workers should pay more attention to the stigma level of T2DM patients, and take effective measures as in controlling glucose levels, and psychological guidance, which can be beneficial to reduction of stigma and depression levels in T2DM patients.