Objective To retrieve, appraise and summarize the best evidence on prevention and management of implantable venous access port-related infection. Methods Such websites or databases as the National Institute for Health and Care Excellence (NICE), the Registered Nurses′ Association of Ontario (RNAO), the Infusion Nurses Society (INS) ,BMJ Best Practice，Cochrane Library,Joanna Briggs Institute Library, the National Center for Biotechnology Information (NCBI),PubMed,China Guideline Clearinghouse (CGC),CNKI,Wangfang Data, VIP database and Chinese Biomedical Literature Database (CBM) were searched to collect literatures including guidelines，best practice information sheet，recommended practices，systematic reviews，and expert consensus statements. Results A total of 7 publications were recruited，including five guidelines，one systematic review and one expert consensus statement and totally 22 items of best evidence, which could be grouped into six categories(risk factors/populations, quality management, placement methods and locations of access ports, port device management, prevention and control of infection, timing of port removal) were summarized. Conclusion Medical staff should dynamically assess the risk factors of infection in patients with implantable venous access port. Meanwhile, it is necessary to select the appropriate placement methods and locations of access ports to fit patients′ conditions, strengthen the quality management and port device management, and standardize the treatment strategy of infection prevention, so as to reduce the incidence rate of port-related infection.