Objective To explore the needs and the influencing factors of sex life after percutaneous coronary intervention in young and middle-aged patients with coronary heart disease. Methods Convenient sampling was used to recruit 221 patients who had received percutaneous coronary intervention. The patients were asked to filled out the self-designed general data questionnaire, the Sex Life Questionnaire and the Sex-Life-Related Health Information Needs Questionnaire. Results Totally, 218 patients(98.64%) expected to get health information guidance for sex life after PCI, 152 (68.78%) had concerns about post PCI sex life recovery, and 127 (57.47%) believed that both patients themselves and spouses should receive health information guidance. The most accepted method to receive health information guidance included written materials and WeChat-based news feed. The total score of sex-life-related health information needs of young and middle-aged patients after PCI was 38.91±5.28. Items of "the risk of sex life after PCI", "the precautions of sex life after PCI" and "the impact of sex life after PCI on the heart" topped the needs chart. Multiple linear regression analysis showed that, age, the number of stents, reasons for hospitalization, heart function classification, type of jobs were major predictors of the score of sex-life-related health information needs of young and middle-aged patients（P<0.05, P<0.01）. Conclusion Young and middle-aged patients with coronary heart disease have strong needs about sex life after PCI. Medical staff should pay more heed to patients who are younger, have more stent implants, have poor cardiac function, and who work a regular job,and give targeted guidance of sex-life-related health information, in an effort to help them restore sex life after PCI, and improve their quality of life.