Objective To evaluate the clinical practice effect of an informationalized and precise quality control model for intravenous therapy. Methods An informationalized and precise quality control model for intravenous therapy was established according to the intravenous nursing standards of practice, the quality control data before (2017) and after (2018) the application of the quality control model were compared. Results After application of the novel quality control model, the time consumption of bedside quality control, quality control results summary and generation of various quality control reports were significantly different from those before the application of the model (P<0.01 for all); clinical nurses′ standard-reaching rate of theoretical knowledge on intravenous therapy, and their standard implementation rate of intravenous therapy related operation were significantly higher than those before the application of the model (P<0.01 for both); and the rate of correctly choosing infusion tools and the incidence of intravenous therapy-related complications were significantly different from those before the application of the model (P<0.01 for both). Conclusion The informationalized and precise quality control model based on the intravenous nursing standards of practice, can increase quality control efficiency for nursing staff, and improve intravenous therapy-related nursing quality.