Objective To evaluate the feasibility of nurse-led removal of urinary catheter. Methods A historical control study was conducted. The control group of 375 cases were given routine removal of urinary catheter, while the intervention group of 293 cases received nurse-led removal of urinary catheter:indications for catheterization were developed according to guidelines, alternatives to indwelling catheter were formulated, daily evaluation of the catheter and measurement of residual urine volume by bladder scanner were conducted, then alternative measures for managing urinary incontinence and retention were implemented. Results The intervention group had lower unreasonable use of urinary catheter and catheter-related urinary tract infection rate, as well as shorter catheter indwelling time （P＜0.01 for all）. Conclusion Implementation of nurse-led removal of urinary catheter can effectively identify key causes of catheter-related urinary tract infection, thus to shorten catheter indwelling time and reduce catheter-related urinary tract infection.