Objective To explore the effect of super-early removal of urinary catheter in patients undergoing lower extremity orthopedic surgery under general anesthesia. Methods A total of 281 patients undergoing lower extremity orthopedic surgery under general anesthesia were divided into an intervention group (n=134) and a control group (n=147) according to the wards they lived in.The intervention group received super-early removal of urinary catheter after the patient could blink eyes following an order, while the control group was given routine removal of urinary catheter at the next day after surgery. Results The duration of catheter indwelling, catheter related bladder discomfort and discomfort during the first voiding were significantly shorter/milder, whereas the recovery of spontaneous urination was longer in the intervention group than the control group (P＜0.01 for all).There was no significant difference in re-catheterization between the two groups (P>0.05). Conclusion Super-early removal of urinary catheter can significantly shorten the duration of catheter indwelling in patients undergoing lower extremity orthopedic surgery under general anesthesia, ameliorate catheter related bladder discomfort and discomfort during first urination, and does not increase re-cathete-rization. It would lead to longer spontaneous urination, but within the normal range.