Objective To explore the methods for management of personal protective equipment（PPE） in designated rescue hospital to combat COVID-19 epidemic. Methods We built an emergency response team, formulated a systematic management process, and managed PPE from such aspects as assessment of requirement and planning, reserve management, allocation management, and donated equipment management. Results More than 5 000 sets of PPE such as gowns were required each day during the peak pe-riod.Until March 1,2020, the supply of PPE could meet the needs of frontline workers in the anti-virus battle, and there was no adverse feedback from the frontline workers such as unqualified equipment or inefficient protective effects. Conclusion Implementing scientific management of PPE can effectively ensure safety of patients and medical professionals.