Objective To investigate the mental health status of front-line nurses in the epidemic situation of Coronavirus Disease 2019 (COVID-19), and to provide reference for taking targeted intervention to improve nurses′ mental health. Methods In the epidemic situation of COVID-19, 175 front-line nurses were investigated using the Psychological Symptom Checklist-90 (SCL-90), the Social Support Rating Scale (SSRS) and the Coping Style Scale. Results The subscale score of somatization and anxiety of the nurses were significantly higher than the norm (P＜0.01 for both), and the total score and subscale score of SCL-90 were significantly correlated with the score of SSRS and the Coping Style Scale (P＜0.01 for all). Conclusion The psychological symptom of somatization and anxiety among front-line nurses are serious in the epidemic situation of COVID-19, and playing the positive role of social support and coping styles is conducive to improving their mental health.