Objective To reduce infection for patients with PICC in outpatient department and nurses during the epidemic of Coro-navirus Disease 2019 (COVID-19), and to avoid PICC catheter occlusion and infection. Methods For 155 patients underwent PICC catheter maintenance during the epidemic, we conducted online management and health guidance through Wechat public platform, made online precise appointments for maintenance time, strengthened occupational protection for PICC specialty nurses, intensified cleaning and disinfection of PICC maintenance room, improved PICC maintenance process and revised related system. Results Du-ring the period of PICC maintenance for the 155 patients, nobody suffered from PICC occlusion or catheter-related infection. Until 2nd March, the PICC maintenance nurses were not infected with novel coronavirus. Conclusion Strengthening infection prevention and control management during COVID-19 epidemic, could avoid PICC related complications and the infection of novel coronavi-rus.