Objective to investigate the continuous nursing needs and quality of life of patients with enterostomy at different time points after discharge, and to explore the correlation among the measurements. Methods A total of 89 patients with permanent enterostomy were selected by convenient sampling, and the general data questionnaire, the Continuous Nursing Needs Scale for Enterostomy Patients, and the City of Hope Quality of Life-Ostomy Questionnaire were used to investigate the patients at 1,3,6 and 12 months after discharge. Results The total scores of continuous nursing needs and quality of life of the patients with permanent enterostomy all had significant differences at different time points, and the two variables were negatively correlated (P＜0.05，P＜0.01）. Conclusion Continuous nursing needs and quality of life of the patients with permanent enterostomy presented a dynamic change over time post discharge.Those with higher needs had lower quality of life. Medical staff need to scientifically evaluate the unmet needs of patients at various time points, and carry out targeted nursing interventions in an attempt to improve the quality of life of patients.