Objective To study the effect of post-discharge community collaborative services led by orthopedic nurse specialists on patients with osteoporotic vertebral compression fracture. Methods A total of 117 patients with osteoporotic vertebral compression fracture were selected and divided into a control group (n=58), who received routine discharge guidance and follow-ups, and an intervention group (n=59), who received medical-partnership-based post-discharge community collaborative services led by orthopedic nurse specialists: a community nursing collaborative service group dominated by orthopedic nurse specialists was built, and the specialists gave training to community nurses, unblocked the channel of information sharing between hospital and communities, and guided community nurses to coordinate the implementation of post-discharge nursing services. The intervention lasted 1 year. Data of the two groups were obtained at completion. Self-management scores, quality of life scores, bone mineral density（BMD） values and the incidence rates of re-fracture were compared between the two groups. Results A year later,self-management scores,quality of life scores in all dimensions, and the average value of BMD in the intervention group were all significantly higher than the control group （P<0.05，P<0.01）, while the incidence rate of re-fracture in the former was significantly lower than the latter (P＜0.05). Conclusion Community collaborative services led by orthopedic nurse specialists can improve post-discharge self-management ability and quality of life of patients with osteoporotic vertebral compression fracture, improve bone density of patients and reduce the incidence rate of re-fracture.