Objective To observe the moxibustion temperature and lasting time under different combinations of ginger puree of different thickness and moxa rolls of varied height and diameter, and to provide references for clinical treatment. Methods A total of 300 healthy volunteers were randomly divided into 10 groups，with 30 people in each group. Ginger puree was prepared and shaped into mound of various thickness. Then moxa rolls of varied height and diameter were placed on the ginger puree at the acupoints of the volunteers before the moxa rolls were lit up. A digital thermometer was used to continuously measure the temperatures of the ginger puree. The time to achieve a temperature of 43℃, and the lasting time of 43-45℃ temperature were recorded. And the pain score of the volunteers was measured at various combinations for the moxibustion therapy. Results Among various combinations of ginger puree and moxa rolls, 6 combinations could achieve a temperature of 43℃, and maintain 43-45℃ for various time. There were significant differences among the combinations （P<0.01, P<0.05）. Among others,the combination of 2.5 cm thick ginger puree and a moxa roll of 2.0 cm in diameter and height could reach 43℃ over a span of （38.24±3.19）min, and maintain 43-45℃ for （21.76±3.06）min; the volunteers reported a pain score of （3.40±0.71） for the combination. Conclusion The best combination is found in 2.5 cm thick ginger puree and a moxa roll of 2.0 cm in diameter and height. This combination can not only reach 43℃ faster, but also maintain a temperature of 43-45℃ longer, and inflict mild pain to the volunteers.