Objective To examine the status and influencing factors of dyadic coping in young and middle-aged lymphoma patients. Methods Totally, 156 young and middle-aged patients with lymphoma were invited to complete the Dyadic Coping Inventory （DCI） and Chinese Version of the Strategies Used by People to Promote Health （C-SUPPH）. Results The total DCI score was 124.00±11.30 and the total C-SUPPH score was 86.46±22.40,showing positive correlation between them （r=0.223,P＜0.01）. Duration of illness, family monthly income and self-management efficacy were factors affecting dyadic coping of patients （adjusted R2=0.261, P＜0.01 for all）. Conclusion The dyadic coping is at moderate level in young and middle-aged patients with lymphoma and needs to be further improved. Interventions on improving self-efficacy of disease management should be taken to enhance dyadic coping of patients with lymphoma in clinical work.