Objective To understand the quality of life among children with strabismus and analyze its influencing factors, so as to provide theoretical evidence for further precise nursing intervention. Methods Totally 113 children with strabismus aged 8-17 waiting for surgery in ophthalmology department of a grade three hospital were selected by convenience sampling, then they were investigated using the general information questionnaire, Child Intermittent Exotropia Questionnaire (Child-IXTQ), Hospital Anxiety and Depression Scale, Simple Coping Style Scale, Social Support Rating Scale and Positive and Negative Emotions Scale. Multiple stepwise regression analysis was used to analyze the influencing factors of quality of life. Results The total score of Child-IXTQ was (61.32±16.31), the dimension score of psychosocial was (62.69±18.17), and visual function was (58.57±19.26). Multiple stepwise regression analysis result showed that, strabismus type, sex, anxiety and emotion were the main influencing factors of quality of life for children with strabismus (P<0.05, P<0.01). Conclusion The overall quality of life of children with strabismus aged 8-17 is low. Medical staff should give targeted precise nursing intervention according to children′s sex, type of strabismus and mental health status, so as to improve their quality of life.