Objective To establish a neurogenic bladder upper urinary tract injury risk management program, and to provide reference for preventing upper urinary tract injury for patients with neurogenic bladder. Methods The indexes were screened and weight were identified using literature review, expert panel discussion, Delphi technique and percentage weight method, then the upper urinary tract injury risk management program for patients with neurogenic bladder was established. Results The recovery rate of the questionnaire in the two rounds was 95.00% and 84.21%, experts′ authority coefficient was 0.87 and 0.88, and the Kendall′s coordination coefficient W for the first level indexes was 0.351 and 0.421 (P＜0.05 for both). The final management program was consisted of 4 first-level indexes, 12 second-level indexes, and 26 third-level indexes. Conclusion The inquiry suggestion of each item in the upper urinary tract injury risk management program for patients with neurogenic bladder tends to be consistent, experts′enthusiasm and authority are high, and the established management program could be used to implement the prevention of the upper urinary tract injury.