Objective To explore the effect of flipped classroom teaching used in children with myopia wearing orthokeratology contact lenses. Methods One hundred and sixty children with myopia wearing orthokeratology contact lenses were divided into a control group and an observation group of 80 chronologically, receiving either routine health education or alternative teaching employed flipped classroom approach. The success rate of lenses warning and satisfaction with nursing service were compared between the two groups.Results The rate of first attempt success and the total success rate, as well as the satisfaction score in the observation group were significantly higher than the control group (P＜0.01 for all). Conclusion Application of flipped classroom approach in children with myopia wearing orthokeratology contact lensescan improve the success rate of lenses wearing and satisfaction of children and their families with nursing work.