Objective To investigate the status and influencing factors of emotional exhaustion among emergency nurses from 3A hospitals in Hubei Province, and to provide reference for formulating targeted intervention to reduce emotional exhaustion for emergency nurses. Methods Totally 492 emergency nurses from 18 3A hospitals in Hubei Province were selected using convenient sampling, then they were investigated using the Maslach Burnout Inventory, The Practice Environment Scale of the Nursing Work Index and the Work Scheduling Flexibility scale. Results The emergency nurses′ emotional exhaustion score was (23.87±12.37), the work scheduling flexibility score was (1.70±0.91) , and the practice environment score was (92.69±16.12). Regression analysis indicated that, educational background, number of night shifts, work scheduling flexibility, adequate manpower and material resources and nursing managers′ability and leadership style in the practice environment were the major influencing factors of emergency nurses′emotional exhaustion (P<0.05，P<0.01). Conclusion Emergency nurses′ emotional exhaustion is at a moderate level, the lower the management level of nursing managers they perceived, the lower the manpower and material security, the lower the flexibility of work scheduling, then the emotional exhaustion they perceived is serious. Nursing managers should focus on improving emergency nurses′ practice environment, implementing a scientific and flexible scheduling mechanism, and reducing their emotional exhaustion.