Objective To discuss the application effect of a mobile health App based on the Omaha system in the health management of patients with cervical spondylotic radiculopathy (CSR). Methods Totally 64 patients with CSR were randomized into a control group (n=31) and an intervention group (n=33). The control group received routine nursing for CSR, while the intervention group received the transitional care additionally using a mobile health App based on the Omaha system. The self-management ability, self-efficacy and the recovery of cervical spine function of the two groups were assessed and compared before and 6 months after the intervention. Results After the intervention, the score of self-management behavior and self-efficacy of the intervention group were significantly higher than those of the control group, while the score of cervical dysfunction index was significantly lower than that of the control group (P<0.05，P<0.01). Conclusion Application of the mobile health App based on the Omaha system in self health management of discharged patients with CSR, is beneficial to enhance patients′self-health management ability and self-efficacy, so as to improve their cervical spine function.