Objective To explore the effect of web-based hospital-community-family management model in patients with depression. Methods One hundred and fifty patients with depression were equally randomized into a control group and an intervention group, receiving either routine follow-up after discharge or web-based hospital-community-family management using App. Medication beliefs and adherence of patients in both groups were evaluated at 1, 3 and 6 months after discharge. Results The score of belief in the necessity of medicine was significantly higher, whereas that of concerns was significantly lower in the intervention group compared with the control group at different time points (P<0.05 for all). The intervention group had higher medication adherence than the control group at 3 and 6 months after discharge (P<0.05,P<0.01). Conclusion Implementation of the web-based hospital-community-family management model in patients with depression can ensure continuity of care, thus to help them adopt correct medication beliefs and enhance medication adherence.