Objective To explore the effect of asthma training for community nurses on management of asthma in children under the regional medical alliance mode. Methods Community nurses who met the asthma nurse requirements were selected from 14 community healthcare centers under the regional medical alliance mode, then they received asthma knowledge and skill training that was developed by asthma team of a children′s hospital launching and leading the medical alliance. After the training, the community nurses provided standardized management for 280 asthma children. Asthma control level, quality of life and medical cost were employed to evaluate the effect after 6 months of follow-up.Results Children′s asthma control test score and quality of life were significantly increased, whereas medical cost was significantly decreased after the intervention (P<0.05 for all). Conclusion Regional medical alliance-driven asthma training for community nurses guarantee quality asthma management for community-dwelling children, thus to control asthma and enhance quality of life of children with asthma.