Objective To implement the best evidence regarding body temperature management into clinical practice for adult patients with severe trauma in an emergency department and to evaluate the application effect. Methods Literature regarding body temperature management for severe trauma patients were retrieved and quality of the literature was evaluated, then 22 recommendations were concluded according to the feasibility, appropriateness, meaningfulness, and effectiveness framework. Barriers were identified in baseline investigation and corresponding action strategies were taken to implement the best evidence into clinical practice. Results The temperature, the scores of the Bedside Shivering Assessment Scale and Cold Discomfort Scale were significantly better at different time points after admittance to the emergency room after the evidence-based practice compared with the controls before the practice (P<0.05 ,P＜0.01). Emergency nurses′ knowledge of body temperature management for severe trauma patients increased from (68.75±8.68) to (90.72±5.52). Conclusion Evidence-based nursing practice standardizes nurse′s practice of body temperature management for trauma patients, thus to reduce hypothermia, shivering and cold discomfort, and to improve nursing quality.