Objective To understand needs for maintenance of dignity in patients with advanced cancer experiencing moderate to severe loss of dignity, and to provide reference for better maintenance of their dignity. Methods A semi-structured in-depth interview was conducted at 10 patients with advanced cancer who experienced moderate to severe loss of dignity, then data were analyzed to extract themes using phenomenological method. Results Three themes including 10 subthemes were identified:disease-related dignity maintenance needs (maintenance of independence, avoidance of symptom distress, and maintenance of informed right and autonomy); family social support needs (family support, peer communication, and medical support); and psychological spiritual care needs (role maintenance, maintenance of self-worth, living in the moment, and inheritance/dedication). Conclusion Needs for maintenance of dignity in advanced cancer patients include symptom control, relative independence and companionship, informed participation and tranquility. Medical staff should provide patient-centered interventions to maintain their dignity.