Objective To reduce the occurrence of nursing interruptions in handover in ICU, and to improve the efficiency of handover. Methods We analyzed the causes of 724 nursing interruptions in 120 routine nursing handovers and then took management specific to the causes. Nursing interruptions in 120 handovers after conducting the management and nurses′ job satisfaction were measured and compared with the baseline values. Results The frequencies and duration of nursing interruptions during handover, as well as time for handover were significantly reduced, whereas nurses′ job satisfaction was significantly improved after the management (P<0.01 for all). Conclusion Management specific to nursing interruptions can effectively reduce the occurrence of interruptive events during handover in ICU and improve work efficiency, thus to enhance job satisfaction of nurses.