Objective To study the effect of interactive voice service system applied in postoperative follow-up for patients undergoing hepatobiliary surgery. Methods An interactive voice service system was employed to provide telephone follow-ups for 632 patients following a self-designed standard communication protocol. Results Four hundred and ninety-eight patients (78.80%) were successfully followed up at the first call, totaling to 534 patients (84.49%) were followed up after the second call, and dialogues in 471 follow-ups (88.20%) can be effectively recognized by the system. The total time of telephone call was 2 049 min and nurses spent about 60 min. Above ninety percent (90.10%) of patients were satisfied with the follow-up using the interactive voice service system. Conclusion Application of interactive voice service system in follow-ups for patients after hepatobiliary surgery can effectively shorten nurses′ time on follow-up, improve work efficiency, and provide high-quality services for patients.