Objective To improve self-management ability of non-dialysis patients with chronic kidney diseases (CKD) and to slow the progression of disease. Methods A total of 420 non-dialysis CKD patients were randomly divided into two groups, with 210 in each. The control group received routine outpatient counselling and follow-up, while the intervention group was subjected to multidisciplinary care including designing a mobile application, establishing electronic health archives, and providing online and face-to-face counselling. The effect was evaluated after 12 months of implementation. Results Two hundred participants in the control group and 208 in the intervention group completed the study. Self-management behavior score, rate of systolic blood pressure control, and the glomerular filtration rate were significantly higher, whereas the concentration of serum creatinine was significantly lower in the intervention group than those in the control group at 6 and 12 months into the intervention (P<0.01 for all). Conclusion Multidisciplinary collaboration combining mobile medical technology applied in non-dialysis CKD patients is beneficial to enhance self-management ability and delay disease progression.