Objective To improve work efficiency of vascular access clinic and patient satisfaction. Methods A total of 212 patients with malignant tumors on chemotherapy through vascular access were divided into a control group of 108 and an intervention group of 104 chronologically. The control group was given routine care in vascular access clinic, while the intervention group received alternative care that employed process reengineering to solve problems in routine care, including multi-channel online appointment, mobile pay, and application of information technology, etc. The effects were evaluated one year after the intervention. Results One hundred and six patients in the control group and 101 cases in the intervention group completed the study. Such four indicators as time for pay, waiting time, frequency of re-visit and patient satisfaction had significant differences between the two groups (P<0.01 for all). Conclusion Employing business process reengineering in improvement of care in vascular access clinic facilitates patients′ clinic visiting, and enhances nursing efficiency and patient satisfaction.