Objective To evaluate the effect of a multi-disciplinary specialist ERAS team run in clinical practice. Methods Five hundred surgical patients on routine ERAS program were treated as the control group, while 750 counterparts receiving care that was provided by a multi-disciplinary specialist ERAS team were served as the intervention group. The team consisted of 6 sub-groups and worked in 13 surgical wards. The levels of specialty knowledge and professional identity of nurses, as well as ERAS related evaluation indexes of the patients were compared between the two groups. Results Nurses had significant improvements in specialty knowledge and professional identity after the intervention (P<0.01 for both). The intervention group showed shorter preoperative fasting and dwell urinary catheter time, earlier out-of-the-bed mobilization after the surgery, lower incidence rates of intraoperative hypothermia, moderate to severe postoperative pain intensity, malnutrition, and deep vein thrombosis, as well as less postoperative hospital stay and medical cost compared with the control group （P<0.05，P<0.01）. Conclusion The practice of multi-disciplinary specialist ERAS team can effectively promote nurses′professional competency, guarantee ERAS implementation, and improve outcome of the patients.