Objective To investigate relationship among demoralization status, health locus of control and fatigue among elderly patients with chronic obstructive pulmonary disease（COPD）, and to provide references for fatigue-mitigating measures by medical staff. Methods A convenient sampling method was used to select 249 elderly patients with stable COPD. The participants were asked to fill out the Demoralization Scale, the Multidimensional Health Locus of Control (MHLC), the Multidimensional Assessment of Fatigue (MAF) Scale, and the self-designed demographic questionnaire. Results The elderly COPD patients scored （3.87±0.83）,（3.78±1.00）, and （3.67±1.07） points in demoralization, health locus of control, and fatigue respectively.There was a significantly positive correlation between demoralization or health locus of control, and fatigue in elderly COPD patients（P＜0.01 for all）. Conclusion Demoralization, health locus of control, and fatigue were slightly above medium levels in elderly COPD patients.The stronger levels of demoralization and health locus of control, the more intense the fatigue level. Medical staff should take measures to stoke the elderly′s enthusiasm in self-management of the diseases, reinforce health education, make them grasp basic nursing knowledge and skills, encourage them to join in activities within their power, in an effort to reduce their dependence on others, arouse sense of meaning in life, and finally mitigate fatigue level and improve psychosomatic well-being.