Objective To explore the effect of WeChat-based small program of logistics service platform applied in precise management of operating room instruments and equipments. Methods The operating room instruments and equipments were divided into a pre-implementation group （from January 2017 to December 2017, 98 pieces）, which was managed by the conventional equipment management process, and a post-implementation group（from January 20 to December 2018, 107 pieces）, which was managed with a WeChat-based small program of logistics service platform. Results The rate of qualified maintenance of medical equipments in the operating room increased from pre-implementation 68.4% to post-implementation 95.3%; the rate of timely maintenance increased from 77.4% to 94.4%; and doctors′ satisfaction increased from 68.0% to 84.0%, and operating room nurse′s satisfaction increased from 68.8% to 88.0%. All the indicators had significant pre-and-post-implementation differences （P＜0.01 for all）. Conclusion Application of WeChat-based small program of logistics service platform in precise management of operating room instruments and equipments,could improve the maintenance and management level of operating room instruments equipment, make it more standardized and systematic, improve work efficiency, and ensure the safety of equipment use.