Objective To assess the effect of an early activity intervention based on HELP protocol on hospitalization-associated disability in very old patients. Methods Totally,420 very old (age ≥80 years) patients who met the inclusion criteria were randomly divided into 2 groups （210 cases each）.The control group was given routine care,while the intervention group was given early coordinated multidisciplinary activity intervention. Activities of daily living scores at discharge and 3 months after discharge were compared between the two groups. Results At discharge, Barthel Index scores of the two groups had significant difference （P＜0.01）; 3 months after discharge, Barthel Index scores and IADL scores of the two groups had significant difference （P＜0.01 for both）. Conclusion The implementation of early coordinated multidisciplinary activity intervention can effectively prevent the decline of activities of daily living related to hospitalization, maintain the function of the very old patients, and improve their quality of life.