Objective To investigate preferences for place of death and the predictors among patients with advanced malignant cancer. Methods A total of 775 patients with advanced malignant cancer were selected by convenience sampling from oncology departments from two hospitals in Hubei province.The revised End of Life Preferences Interview （ELPI） was used to investigate patients′ pre-ferences for places of death and other end-of-life wishes. Results As high as 79.61% of the patients wished to die at home, and 20.39% opted for other places. Factors influencing the preferences of death place were as follows: whether being informed of terminal treatment and nursing problems or not by the doctors, family income, educational attaiment, places of residence, and genders （P＜0.05,P＜0.01）. Conclusion A majority of cancer patients wished to die at home, and some opted for other places,as in hospitals, nur-sing homes, and so on. Health care workers should communicate with patients about their diseases appropriately, so that patients have a full understanding of their own conditions and make decisions of their own accord.Popularizing and developing home care is an important way to ensure the quality of home-based end-of-life care.