Objective To understand the status and the influencing factors of demoralization in post-operative colorectal cancer patients, and to provide evidence for targeted interventions. Methods A total of 212 post-operative colorectal cancer patients were investigated with the general information questionnaire, the Demoralization Scale （DS）, the Social Support Scale （SSRS） and the Medical Coping Modes Questionnaire （MCMQ）. Results Patients′demoralization score was （32.50±14.18）, which was negatively correlated with confrontation of MCMQ and social support （P＜0.01 for both）. The main influencing factors of demoralization were length of post-surgery period, stages of disease, whether to have a stoma, confrontation and social support （adjusted R2=0.510）. Conclusion Post-operative colorectal cancer patients experienced severe demoralization. Measures should be taken to assuage demoralization in these patients, and promote their mental health.