Objective To evaluate the effects of blended instruction based on an online teaching platform for the course of nursing interpersonal communication practice. Methods Totally, four classes of the 2017 year were randomly divided into a control group （two classes, n=103）and an intervention group （two classes, n=99）. The traditional teaching method was applied to the control group, while blended instruction based on the UMOOC platform was applied to the intervention group. Results Practice test scores, and humanistic caring scores in the intervention group were significantly higher than those in the control group （P＜0.01 for all）; 90.0% of the intervention group students believed that blended instruction based on the UMOOC platform could improve their learning interest, course involvement, self-directed learning, and team working, etc. Conclusion Blended instruction based on the UMOOC platform could improve students′ practice ability and humanistic caring ability.