Objective To investigate orthopedic professionals′ knowledge of pain management, to explore the influencing factors, and to provide evidence for formation of a clinical management system of orthopedic pain. Methods Totally, a stratified random sampling method was used to select 411 orthopedic professionals from six different hospitals in Wuhan.The Chinese version of Know-ledge and Attitudes Survey Regarding Pain（KASWP） was used to collect data that was analyzed with multiple linear regression analysis. Results The pain knowledge scores ranged 12-26（18.60±3.39） points.Survey items with a correct rate less than 30% accounted for 32.50% of the total items. There was no significant difference between the scores of doctors and nurses （P＞0.05）.Pain management among orthopedic medical staff was mainly related to the hospital levels, educational levels, sub-majors, marital status and ages （P＜0.05，P＜0.01）. Conclusion Orthopedic professionals had poor knowledge and management level of pain, which needs to be improved. It is necessary to strengthen systematic training on pain knowledge, promote integration of pain ma-nagement by doctors, nurses and patients, and boost effective pain management.