Objective To explore the effect of performance evaluation of nurses based on ICU sub-specialty post management model. Methods A convenient sampling method was used to select 35 nurses in intensive care unit as research subjects to form sub-specialty working groups. An ICU sub-specialty post management model was established, and the nurses were subjected to performance evaluation based on the model. Results After one year′s implementation, the scores of nursing quality indexes, and nurses′ satisfaction with performance evaluation based on the sub-specialty post management model, were significantly higher than before （P＜0.01 for both）. Conclusion The performance evaluation based on the ICU sub-specialty post management model helps to improve the quality of ICU nursing care and nurses′ satisfaction.