Objective To develop a multisystem based nursing performance appraisal information system and to evaluate its clinical application effect. Methods〖WTBZ〗 Four wards were treated as the control group and employed Microsoft Office Excel for nursing performance appraisal, and 4 wards were served as the experimental group and utilized a novel multisystem based information system for nursing performance evaluation, including HIS system, mobile nursing system, nursing scheduling system, nursing quality management system and patient satisfaction survey system. Average monthly time spent on performance appraisal, deviation rate of the results and nurses′ satisfaction with performance appraisal were compared between the two groups in the year of 2017. Results The experimental group showed shorter time of performance appraisal, lower deviation rate and higher nurses′ satisfaction compared with the control group (P<0.01 for all). Conclusion The multisystem based nursing performance appraisal information system achieves automatic calculation of nursing performance, thus to shorten performance appraisal time, decrease deviation of the results, improve nurses′ satisfaction, and enhance efficiency of nursing management.