Objective To improve the preventive effect of incontinenceassociated dermatitis (IAD) and pressure injury (PI) in intensive care patients, and to promote recovery of patients. Methods A total of 1 541 ICU patients were divided into a control group of 758 and an observation group of 783 chronologically, receiving either routine care or alternative care followed the novel skin management process. Incidence of IAD and PI in the two groups during hospitalization were compared. Results The incidence rates of IAD and PI were 8.58% (65 cases) and 6.46% (49 cases) in the control group, versus 4.98% (39 patients) and 4.34% (34 patients) in the observation group. There were significant differences in IAD incidence as well as in severity of IAD and PI between the two groups (P<0.01 for all). Conclusion Implementation of skin management process can reduce the incidence or severity of IAD and PI, thus to promote recovery of patients.