Objective To enhance medication adherence and management ability of patients with schizophrenia. Methods Eighty stable patients with schizophrenia were randomized into a control group and an intervention group of 40, receiving either routine nursing care or a medication management promotion program in which drug storage box and card was distributed at discharge, and text message was sent every week to remind patients to take medicine on time after discharge. Results After 4 weeks of intervention, the intervention group had better medication management knowledge, lower total Positive and Negative Symptoms Scale score and positive symptoms score, and higher medication adherence compared with the control group (P<0.05,P<0.01). Conclusion The medication management promotion program can effectively enhance medication selfmanagement and adherence of patients with stable schizophrenia, thus to alleviate their symptoms.