Objective To determine the impact of health literacy, selfefficacy, selfmanagement and social support on quality of life (QOL) in coronary heart disease (CHD) patients. Methods A total of 280 CHD patients were recruited using convenience sampling method and were investigated using the sociodemographic data questionnaire, CHD Health Literacy Questionnaire, Coronary Artery Disease Self-management Scale (CSMS), Chronic Disease Selfefficacy Scale (CDSS), Social Support Rating Scale (SSRS) and European Quality of Life 5Dimensions Scale(EQ5D). Structural equation modeling (SEM) was used to analyze the relationships among the variables. Results Factors influencing QOL were selfmanagement, health literacy, selfefficacy, social support, education, age, average monthly income and number of comorbidities. Selfmanagement and social support had a direct effect on QOL, with the coefficient for direct effect being 0.644 and 0.355 respectively. Health literacy indirectly affected QOL through selfefficacy, selfmanagement and social support, with the coefficient for total effect of 0.479. Selfefficacy also had an indirect effect on QOL through selfmanagement, with the coefficient for total effect being 0.414. Education level, age, average monthly income and number of comorbidities were also affected QOL, with the coefficients for total effect being 0.167, -0.126, 0.091 and -0.058, respectively. Conclusion QOL of CHD patients was affected by several factors, so targeted interventions should be taken to enhance their health literacy, selfefficacy and selfmanagement, thus to improve QOL.