Objective To evaluate the effect of multidisciplinary cooperative intervention on the rehabilitation outcome of lumbar surgery patients with kinesiophobia. Methods A total of 172 postoperative kinesiophobia patients after lumbar fusion surgery in the department of spine surgery were divided into an observation group and a control group chronologicall, with 86 patients in each group. The control group received routine nursing and follow up, while the observation group additionally received the intervention formulated by spinal surgeons, anesthesiologists, rehabilitators, psychological counselors, nurses, and others. Patients′ kinesiophobia, lumbar spine rehabilitation and quality of life were evaluated at 24 hours after surgery, 1 month, 3 months, and 6 months after discharge respectively. Results At 1 month, 3 months and 6 months after discharge, the TSK score of the observation group were significantly lower than those of the control group, and the score of JOA were significantly higher than those of the control group （P＜0.01 for all）;at 3 months and 6 months after discharge, the quality of life score of the observation group were significantly higher than those of the control group （P＜0.01 for both）. Conclusion The multidisciplinary cooperative intervention could reduce the degree of postoperative phobia for patients after lumbar surgery, improve their rehabilitation outcome and quality of life.