Objective To explore the status and influencing factors of multicultural nursing cognition among clinical nurses in the pearl river delta region, and to provide reference for conducting multicultural nursing training. Methods Totally 381 clinical nurses from 4 tertiary general hospitals in the pearl river delta region were investigated using a self-designed multicultural nursing cognition questionnaire of clinical nurses. Results The total score of multicultural nursing cognition among clinical nurses in the pearl river delta region was（69.48±14.36）,the scoring rate for the dimension of theoretical knowledge was 48.93%, 61.68% for customs, 70.96% for verbal communication, and 77.65% for dietary culture. Working city, age, professional title, whether satisfied with nuring work and reading habits were the main influencing factors of multicultural nursing cognition of clinical nurses （P＜0.01，P＜0.05）. Conclusion The overall multicultural nursing cognition level among clinical nurses in the pearl river delta region is at a middle. Nursing administraters should strengthen on-job training according to nurses′ weakness of multicultural nursing cognition,so as to improve nurses′ cognitive and practical level of multicultural nursing.