Objective To conduct project management on risk prevention and control for locks of washrooms in wards, and to prevent accident occurring in patients′ washroom. Methods Totally 106 wards in the hospital were checked on site, and primary nurses′ problems on risk prevention and control for locks of washrooms in wards were collected and root cause analysis was conducted. A project management team was established and project management measures were formulated, then the locks management, the configuration requirements and location of keys, and daily management were refined and standardized. Clinical nurses′ awareness rate on location of keys to the washrooms, the function of the universal keys to the washrooms and nurses′ success rate of opening the door at one time after the project management were assessed. Results All the locks of the washrooms were opened using the universal keys, the keys were placed in the emergency box uniformly, and all were in the same place, and all the primary nurses in the wards could open the locks at one time. Conclusion Project management on risk prevention and control for locks of washrooms in wards is conducive to enhancing nurses′ participation in safe management, it could promote the risk prevention and control interventions taking into action effectively, and ensure patients′ safety.