Objective To construct an effective supervision mode for nursing quality, to promote nursing quality management level and improve continuous quality improvement. Methods The clinical nursing quality supervision standards,supervision experts, supervision objects, supervision methods, supervision results and supervision improvement were integrated multivariatly, which were then implemented in 106 nursing wards of the whole hospital. The implementation rate of nursing quality sensitive indicators and the incidence of adverse events were compared before and after the practice of the mode. Results After the practice of the mode,the implementation rate of nursing quality sensitive indicators were significantly higher than those before the practice, and the incidence of adverse events was significantly lower than that before the practice(P＜0.05, P＜0.01). Conclusion Application of the multivariate integrated supervision mode could monitor the nursing quality from the process and result; it is conducive to promoting ability of nursing managers, encouraging nurses to participate in nursing quality management and improving nursing quality.