Objective To explore the application effect of precise nursing model based on multidisciplinary collaboration in patients with refractory cancer pain. Methods A total of 208 patients with refractory cancer pain treated in analgesia department were divided into a control group and an observation group chronologically, with 104 cases in each group. The control group was given routine nursing for cancer pain, while the observation group received precise nursing by establishing multidisciplinary team. The patients in the two groups were investigated using Brief Pain Index (BPI), Chronic Pain Selfefficacy Scale (CPSS) and European Organization for Research on Treatment of Cancer (EORTC) at 1 month after discharge. Results At 1 month after discharge, the BPI score of the observation group were significantly lower than those of the control group, and the score of CPSS and EORTC were significantly better than those of the control group (P<0.01 for all). Conclusion The precise nursing model based on multidisciplinary collaboration could effectively alleviate pain for patients with refractory cancer pain, improve their selfefficacy and quality of life.