Objective To explore the effect of mindfulnessbased music therapy on cerebral hemorrhage patients with acute stress disorder and sleep disturbance. Methods Seventy cerebral hemorrhage patients with acute stress disorder and sleep disturbance were randomized into a control group and an intervention group, with 35 patients in each group. The control group accepted routine nursing, while the intervention group additionally received mindfulnessbased soothing music training for 14 days. The polysomnography (PSG), Stanford Acute Stress Reaction Questionnaire (SASRQ) and The Pittsburgh Sleep Quality Index (PSQI) were utilized before and after the intervention to measure the difference in each phase of Nonrapid Eye Movement (NREM), subjective sleep quality and acute stress response between the two groups. Results After the intervention, the total SASRQ score of the intervention group was significantly lower than that of the control group,while the proportion of the total sleep time accounting for the recorded time, NREM duration, duration of phase 3 and 4 were significantly more than those of the control group (P<0.05, P<0.01). Conclusion Mindfulnessbased music therapy could effectively increase the deep sleep time and its proportion for cerebral hemorrhage patients with acute stress disorder and sleep disturbance, improve their sleep quality, and relieve their acute stress response.