Objective To evaluate the effect of antenatal group psychological intervention for highrisk pregnant women. Methods Totally 334 highrisk pregnant women were randomized into an intervention group and a control group, with 167 cases in each group. The control group received routine prenatal examination and followup, while the intervention group additionally received 6 times antenatal group psychological intervention course, 5 times were for highrisk pregnant women, and the other one was focused for husbands. The Postpartum Depression Screening Scale (PDSS) was utilized to evaluate the two groups at early and middle pregnancy, late pregnancy, 3 days and 42 days after delivery. Results The PDSS score at late pregnancy, 3 days and 42 days after delivery in the intervention group were significantly lower than those in the control group (P<0.01 for all). There were no significant differences in PDSS score at late pregnancy, 3 days and 42 days after delivery for the highrisk pregnant women attending the course with different frequency and whether their husband participating the course or not (P＞0.05 for all). Conclusion The antenatal group psychological intervention is conducive to decreasing perinatal depression for highrisk pregnant women, while it is necessary to strengthen their treatment compliance and familysupporting system.